A simple and green synthesis of highly functionalized quinoline derivatives using zinc oxide nanoparticles

摘要

A simple and one pot method has been designed for the synthesis of highly substituted quinoline derivatives using ZnO nanoparticles in aqueous medium by means of three component condensation reaction of aromatic aldehydes, malononitrile and substituted anilines via Knoevenagel condensation followed by Michael addition in water. This new method has many advantages over reported methods like easy work-up, operational simplicity and excellent yields with short reaction time.