Enantiospecific first total synthesis of cucumin-H

摘要

Enantiospecific first total synthesis of the linear triquinane sesquiterpene cucumin-H. has been described. (R)-Limonene has been employed as the chiral starting material and a combination of Claisen rearrangement, intramolecular cyclopropanation and Nazarov reactions are employed for the regio- and stereospecific construction of the triquinane framework.