Synthesis, characterization and biological screening of some novel tetrahydroquinazoline derivatives

摘要

Synthesis of a series of novel 4-aryl-5,5-dimethyl-7-(2'-piperidin-1'-yl-cthyl)-2-hydroxy-3,4,5,6-tetrahydroquinazolines 2a-i has been efficiently accomplished by condensation of 5,5,7-trimethyl-4-aryl-3,4,5,6-tetrahydroquinazolin-2-ols 1a-i with paraformaldehyde and pipcridine in the presence of conc. HCl. All the synthesized compounds have been characterized by elemental analyses, IR, ~1H NMR and mass spectroscopic investigation. All the compounds 2a-i have been evaluated for their antimicrobial and antilubcrcular activity.