Formation and antimicrobial activity of 2-azetidinones from selective ester cleavage in 1,3,3-trisubstituted 4-[2'-(o-diarylacyl)hydroxyphenyl]-2-azetidinones

摘要

Treatment of the 1,3,3-trisubstituted 4-[2'-(O-diarylacyl)-hydroxyphenyl]-2-azetidinones with sodium hydroxide in ethanol at room temperature lead to selective cleavage of the ester linkage in the substrates forming new 1,3,3-trisubstituted 4-(2'-hydroxyphenyl)-2-azetidinones,which have been characterized on the basis of analytical and spectral(IR,~1H and ~(13)C NMR,MS)data.The structure elucidation also involves application of the HMQC and HMBC studies using 2-D NMR(~1H-~(13)C COSY)spectra.The antibacterial and antifungal activities of the products are reported.