Selective hydroboration / oxidation of double bond in the presence of triple bond by sodium acetoxyborohydride leading to the synthesis of acetylenic alcohols

摘要

Selective hydroboration of carbon-carbon double bond has been achieved in the presence of carbon-carbon triple bond using in situ generation of sodium acetoxyborohydride from sodium borohydride and acetic acid in dry THF at 0°C followed by oxidation with alkaline hydrogen peroxide.