Pyrrolidine catalyzed regioselective and diastereoselective direct aldol reaction in water

摘要

Pyrrolidine catalyzed direct aldol reaction of methyl ketones other than acetone with 4-nitrobenzaldehyde in water affords linear aldol addition product arising from the selective attack of the unsubstituted carbon of the unsymmetrical ketone. The present methodology provides an experimentally simple and green process for regioselective synthesis of beta-hydroxyketones in water.