Reaction and antimicrobial activity of 1-arylethylene benzofuranyl ketone derivatives

摘要

Interaction of benzalvisnaginone or khellinone derivatives with thiourea gives the tetrahydropyrimidin-2-thione derivatives which are condensed with chloroacetic acid in acetic anhydride to form thiazolo[3,2-a]pytimidin-3-one.Its behaviour towards benzaldehyde,and aromatic amine is discussed.While the reaction of the benzalvisnaginone derivative with quanidine yields 2-amino-pyrimidine and its reaction with 2,3-dichloro-1,4,-naphtha-quinone and 2-aminothiazole chloroacetamide,is investigated.The compounds are tested for their antibacterial activity.