Steroid and aliphatic esters from the seeds of Nigel la sativa

摘要

Three novel compounds,one steroid and the other two aliphatic esters,have been isolated from the seeds of Nigella sativa and identified as ergosta-5,24(28)-dien-2,3-cis-diol 1,pentyl undecanoate 2,methyloctadeca-14,16-dienoate 3,on the basis of spectral and chemical analysis.The compound 2 exhibits significant activity against Staphylococcus aureus and Shigella spp,while moderate activity against Escherichia coli has been recorded.Rest of the compounds show poor activity against all the tested bacteria.