A facile synthesis of steroidal pyrazoles,isoxazoles and pyrimidines from testosterone

摘要

Synthesis of 17beta-hydroxy-androst-4-eno[3,2-c]pyrazole 3,17beta-hydroxy-androst-4-eno[3,2-c]-[1'H]-5'-methylthiopyrazole 4,17beta-hydroxy-androst-4-eno[2,3-d]isoxazole 5,17beta-hydroxy-androst-4-eno[2,3-d]-[1'H]-3'-methylthio isoxazole 6,17beta-hydroxy-androst-4-eno[3,2-d]-2'-amino-6'-ethoxypyrimidine7,17beta,2'-dihydroxy-androst-4-eno[3,2-d]-6'-ethoxypyrimidine 8,17beta-hydroxy-androst-4-eno[3,2-d]-2'-thiolo-6'-ethoxypyrimidine 9,17beta-hydroxy-4-androsteno[3,2-d]-2'-amino-6'-ethoxypyrimidine 10,17beta,2'-Dihydroxy-4-androsteno[3,2-d]-6'-ethoxypyrimidine 11 and 17beta-hydroxy-4-androsteno[3,2-d]-2'-thiolo-6'-ethoxypyrimidine 12,from 2-ethoxymethylene-4-androsten-3-one 1 and 2-bis(methylthio)methylene-4-androsten-3-one 2 are reported.