Antimicrobial screening and synthesis of some novel benzo[a]phenothiazines and ribofuranosides

摘要

Synthesis of 6-(4-chloro-2-methoxy-5-methylanilino/2-methoxy-5-methylanilino)-9-chloro-5H-benzo[a]phenothiazin-5-thione,12H-benzo[a] phenothiazin-5-ols,5-acetoxy-12H-benzo[a] phenothiazines and 5-methoxy-12H-benzo[a]pheno-thiazines have been carried out from 6-(4-chloro-2-methoxy-5-methylanilino/2-methoxy-5-methylanilino)-9-chloro-5H-benzo[a] phenothiazin-5-ones;which have been synthesized by condensing zinc mercaptide of 2-amino-5-chloro-benzenethiol and 2-(4-chloro-2-methoxy-5-methylanilino/2-methoxy-5-methylanilino)-3-chloro-1,4-naphthoquinone.The ribofuranosides viz,N-(2',3',5'-tri-O-bcnzoyl-beta-D-ribofuranosyl)-6-(4-chloro-2-methoxy-5-methylanilino/2-methoxy-5-methylanilino)-9-chloro-5-acctoxy/5-mcthoxy-12H-benzo[a]phenothiazines have been synthesized by condensing synthesized hetcrocycles bases with (+)-beta-D-ribofuranose-1-acctate-2,3,5-tribenzoate.Structural assignments have been done on the basis of elemental analysis,IR,and ~1H NMR.All the synthesized compounds have been screened for their antimicrobial activity.