Synthesis of 4H-imidazo[2,1-c][1,4]benzo-xazin-4-yl acetic acids and esters as possible COX-2 inhibitors

K N Jayaveera; S Sailaja; P Reddanna; D Bharat Reddy; G Jagath Rcddy; K Srinivasa Rao

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Synthesis of 4H-imidazo[2,1-c][1,4]benzo-xazin-4-yl acetic acids and esters as possible COX-2 inhibitors

机译：可能作为COX-2抑制剂的4H-咪唑并[2,1-c] [1,4]苯并恶嗪-4-基乙酸和酯的合成

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A scries of 4H-imidazo[2,1-c][1,4]benzoxazin-4-yl acetic acids and esters (7 and 8) have been synthesized from methyl alpha-(3,4-dihydro-3-oxo-2H-1,4-benzoxazin-2-yl)acctales 5 and their COX-2 inhibition activities are evaluated.

机译：由甲基α-（3,4-二氢-3-氧代-）合成了一系列的4H-咪唑并[2,1-c] [1,4]苯并恶嗪-4-基乙酸和酯（7和8）。评价了2H-1，4-苯并恶嗪-2-基）5及其对COX-2的抑制活性。

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《Indian Journal of Chemistry, Section B. Organic Including Medicinal》 |2006年第3期|共4页
作者
K N Jayaveera; S Sailaja; P Reddanna; D Bharat Reddy; G Jagath Rcddy; K Srinivasa Rao;
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正文语种 eng
中图分类化学;
关键词
Imidazo acetic acids; benzoxazin acetates; COX-2 inhibition activity;

机译：咪唑乙酸;苯并嗪乙酸酯;COX-2抑制活性;

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1. Synthesis of 4H-imidazo[2,1-c][1,4]benzo-xazin-4-yl acetic acids and esters as possible COX-2 inhibitors [J] . K N Jayaveera, S Sailaja, P Reddanna, Indian Journal of Chemistry, Section B. Organic Including Medicinal . 2006,第3期

机译：可能作为COX-2抑制剂的4H-咪唑并[2,1-c] [1,4]苯并恶嗪-4-基乙酸和酯的合成
2. Synthesis and analgesic activity of 2-methyl-2-(1-(3-benzoyl-4-substituted-1,4-dihydropyridyl))acetic acid methyl esters, acetic acids, and acetamides. [J] . Agudoawu SA, Yiu SH, Wallace JL, Archiv der Pharmazie . 1999,第6期

机译：2-甲基-2-（1-（3-（苯甲酰基-4-取代的1,4-二氢吡啶基））乙酸甲酯，乙酸和乙酰胺的合成和止痛活性。
3. Synthesis of 2-methyl-2-[1-(3-benzoyl-4-phenyl-1,4-dihydropyridyl)]acetic acid methyl ester, acetic acid, and acetamide analogs as potential antiarthritic agents [J] . Agudoawu SA, Yiu SH, Knaus EE Canadian Journal of Chemistry . 1997,第8期

机译：2-甲基-2- [1-（3-苯甲酰基-4-苯基-1,4-二氢吡啶基）]乙酸甲酯，乙酸和乙酰胺类似物的合成作为潜在的抗关节炎药
4. A facile synthesis of diastereoisomeric sulfur containing stable 1,4-diionic organophosphorus compounds through the reaction of 1,3-diethyl-2- thiobarbituric acid and activated acetylenic esters in the presence of triphenylphosphine(Abstracts) [C] . Nourollah Hazeri, Malek Taher Maghsoodlou, Sayyed Mostafa Habibi Khorassani European Symposium on Organic Chemistry . 2007

机译：通过1,3-二乙基-2-硫脲脲酸和在三苯基膦（摘要）存在下，通过1,3-二乙基-2-硫脲脲酸和活化的乙炔酯的反应，含有稳定的1,4-二硫酸有机磷化合物的非对映异构体硫的合成。
5. Manganese triacetate-mediated oxidative and dehydrative cyclizations of nitroacetate esters; manganese triacetate-mediated lactonization of chloro- and dichloro-acetic acid with alkenes; total synthesis of (+/-)-cladobotryal, (+/-)-CJ16,169 and (+/-)-CJ16,170; synthesis of (+/-)-deoxysymbioimine. [D] . Che, Qinglin. 2006

机译：三乙酸锰介导的硝基乙酸酯的氧化和脱水环化；三乙酸锰介导的氯乙酸和二氯乙酸与烯烃的内酯化；（+/-）-锁骨肌，（+/-）-CJ16,169和（+/-）-CJ16,170的总合成; （+/-）-脱氧共生亚胺的合成。
6. Re‐evaluation of acetic acid lactic acid citric acid tartaric acid mono‐ and diacetyltartaric acid mixed acetic and tartaric acid esters of mono‐ and diglycerides of fatty acids (E 472a‐f) as food additives [O] . EFSA Panel on Food Additives and Flavourings (FAF), Maged Younes, Gabriele Aquilina, 2020

机译：重新评估乙酸乳酸柠檬酸酒石酸单糖苷和二乙酰甘氨酸单甘油和脂肪酸甘油三酯的混合醋酸和酒石酸酯（E 472A-F）作为食品添加剂
7. Synthesis of 2-(6-Acetamidobenzothiazolethio)acetic Acid Esters as Photosynthesis Inhibitors [O] . Eva Sidoova, Katarina Kralova, Dusan Loos 2013

机译：光合作用抑制剂2-（6-乙酰胺基苯并噻唑硫基）乙酸酯的合成
8. Results of an Acute Toxicity Study in Fish with Mixture Containing Acetic Acid, C6-8-branched Alkyl Esters and Alcohols, C6-8-branched with Acetic Acid, C6-8-branched Alkyl Esters (Asterisk 3); Alcohols, C6-8-branched. [R] . 2011

机译：含有乙酸，C6-8-支链烷基酯和醇的混合物的鱼类急性毒性研究结果，C6-8-支链与乙酸，C6-8-支链烷基酯（星号3）;醇，C6-8-支链。

Synthesis of 4H-imidazo[2,1-c][1,4]benzo-xazin-4-yl acetic acids and esters as possible COX-2 inhibitors

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