A facile synthesis of 4-oxo-1,2,3,4-tetrahydropyrido [3',2':4,5] furo[3,2-d]pyridines:a new tricyclic heterocyclic ring system

摘要

2-Acetyl-3-amino-4-trifluoromethyl-6-substitutedphenylfuro[2,3-b]pyridines are subjected to Claisen-Schmidth condensation with different arylaldehydes followed by intramolecular Michaeltype addition to obain 4-oxo-1,2,3,4-tetrahydropyrido [3,2';4,5]furo[3,2-d]pyridines,a new tricyclic heterocyclic ring system of biological interest. The studies directed towards the synthesis of pyridofuropyrazoles have also been discussed.