Organoselenium compounds based on substituted acetanilides: Synthesis, characterization and antioxidant activity

摘要

A series of organoselenium compounds based on substituted acetanilides of compositions, Se{(CH2)_nCONHC6H4X}_2 (n = 1, 2) and (SeCH2CH2CONHC6H4X)2 (X = OH/ NH2) have been synthesized and characterized by microanalyses, IR, NMR (~1H, ~(13)C{~1H}, ~(77)Se{~1H}) spectroscopy and mass spectrometry. Antioxidant activity of these compounds has been evaluated against DPPH radicals in vitro. Some of these compounds exhibit better inhibition of DPPH radicals than standard BHT. The selenide, analogous to paracetamol, (p-HOC6H4NHCOCH2)_2Se, exhibits the highest antioxidant capacity in a given series.