Heterocyclic systems containing bridgehead nitrogen atom: Synthesis and biological activities of some substituted s-triazolo[3,4-b][1,3,4]thiadiazoles

摘要

Various 3-alkyl/aryl-6-(2-chloro-2-substituted-phenyl ethenyl)-5, 6-dihydro-s-triazolo [3,4-b][1,3,4]thiadiazoles 3 have been synthesised by the condensation of 3-substituted-4-amino-5-mercapto-1,2,4-triazoles 1 with various substituted #beta#-chlorocinnamaldehydes 2 in benzene containing a catalytic quantity of p-TsOH suing Dean-Stark apparatus. Structures of thiadiazoles 3 have been established on the basis of analytical and spectral data. The thiadiazoles 3 have been assessed for antiinflammatory, antibacterial and antifungal activities.