Solvent-free synthesis of 2',3',5'-tri-O-acetyl -2,6-dichloropurine nucleoside catalyzed by p-toluenesulfonic acid using microwave

摘要

Starting from tetraacetylribofuranosc 1 and 2,6-dichloropurine 2,in the presence of p-toluenesulfonic acid (p-TsOH),2',3',5'-tri-O-acetyl-2,6-dichloropurine nucleoside 3 has been synthesized in microwave oven for the first time.On comparing(-> Comparing) with the conventional methods,this method has advantages such as shorter reaction time (4.5min),better yield (83.5%),simple(-> simpler) workup and environmental acceptability.