A retrospective study was conducted of 308 eyes with pathologic myopia obtained from 202 patients (23 surgical eyes; 285 post mortem eyes) over a 67-year period. Histopathologic findings and percentage of eyes affected, in decreasing order of frequency, were myopic configuration of the optic nerve head, 37.7percnt;; posterior staphyloma, 35.4percnt;; degenerative changes of the vitreous, 35.1percnt;; cobblestone degeneration, 14.3percnt;; myopic degeneration of the retina, 11.4percnt;; retinal detachment, 11.4percnt;; retinal pits, holes, or tears, 8.1percnt;; subretinal neovascularization, 5.2percnt;; lattice degeneration, 4.9percnt;; Fuchs spot, 3.2percnt;; and lacquer cracks, 0.6percnt;. The reasons for enucleation in the surgically obtained eyes included, in decreasing order of frequency: degeneration after retinal detachment; secondary glaucoma; endophthalmitis; postsurgical epithelial ingrowth; expulsive hemorrhage; degeneration after cataract extraction; and presumed intraocular tumor. Clinicopathologic correlations are discussed.
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