Novel synthesis of fused ring [1,4]benzothiazines/[1,4]benzoxazines and related heterocycles

摘要

The interaction of 1,3-disubstituted-5-bromo-2-thioxo-barbituric acid with o-aminothiiophenols and o-aminophenol affords 5,-disubstituted-8-oxo-6-thioxo-pyrimido[5, 4-b](1,4) benzothiazines and 5,7-disubstituted-8-oxo-6-thioxo-pyrimido[5,4-b](1,4)-benzoxazines, respectivley. The reaction of 5,5-dibromo-1,3-disubstituted-2-thioxo-barbituric acid, with o-aminothiiophenols and o-aminophenol is discussed. The compounds have been characterised by chemical reactions and spectral studies.