Synthesis of some novel bridgehead nitrogen heterocyclic systems containing 1,8-naphthyridine moiety

摘要

3-Aryl-2-chloro-1,8-naphthyridines 3 on treatment with anthranilic acids, o-phenylenediamine and sodium azide afford quinazolino[3,2-a][1,8]naphthyridin-13-ones 4, benzimidazo[1,2-a][1,8]naphthyridines 5 and tetrazolo[1,5-a][1,8] naphthyridines 6 respectively. The structures of compounds 4-6 have been established by IR, ~1H NMR and mass spectral data. The compounds 4 have been evaluated for their antibacterial activity.