Synthesis and biological activities of some 2-chloro-6/8-substituted-3-(3-alkyl/aryl-5,6-dihydro-s-triazolo-[3,4-b][1,3,4]thiadiazol-6-yl)quinolines

摘要

Various 3-substituted-4-amino-5-mercapto-1,2,4-triazoles 2 when condensed with substituted 2-chloro-3-formylquinolines 1 in DMF or DMF/K_2CO_3 give 2-chloro-6/8-substituted-3-(3-alkyl/aryl-5,6-dihydro-s-triazolo[3,4-b][1,3,4]thiadiazo-6-yl)quinolines 3. The quinolines 3 have been assessed for their antiinflammatory, antibacterial and antifungal activities.