A convenient one step anoidc synthesis of 3-alkyl indoles

摘要

3-Alkyl indoles have been synmthesized anodically by co-electrolysis of indole-3-propanoic acid 1 and mono carboxylic acids 2a-2f viz. propanoic acid 2a, hexanoic acid 2b, nonanoic acid 2c, decanoic acid 2d, dodecanoic acid 2e and hexadecanoic acid 2f at platinum, titanium and graphite. The dimeric products obtained are viz. 1,4 (3'-diindolyl) butane 1', alkanes 2'a-2'f and 3-alkyl indoles 3'a-3'f. These products have been separated by column chromatography using different solvents and characterized by IR, ~1H NMR and elemental analysis. These studies have suggested that the desired product 3'a-3'f is obtained in 33-60% yield at platinum anode at current density 0.1111 A.cm~(-2).