Synthesis of pyrazoline,pyrimidine and 1,5-benzodiazepine derivatives of 1,8-naphthyridine and evaluation of antibacterial activity

摘要

A series of 1-aryl-2,2-bis-(1,8-naphthyridin-2-yl)ethenes 4,5-aryl-3-methyl-4-(1,8-naphthyridin-2-yl0-1-phenyl-2-pyrazolines 5,5,6-dihydro-6-aryl-4-methyl-5-(1,8-naphthyridin-2-yl)-2-thioxpyrimidines 6 and 2,3-dihydro-2-aryl-4-methyl-3-(1,8-naphthyridin-2-yl)-1H-1,5-benzodiazepines 7 have been synthesized from 2-aminonicotinal dehyde 1 via alpha-91,8-naphthyrindin-2-yl) banzalacetones 3. The benzalacetones 3 have been characterized on the basis of elemental analyses,IR,~1H NMR and MS. The compounds 4,5, and have been screened for their antibacterial activity.