Synthesis of some novel 1-aminomethyl-3-benzoylhydrazono-2-indolinones as potential antiinflammatory agents

摘要

Acid-catalysed condensation of hydrazides 3, obtained from substituted phenoxybenzoic acids 1 with indolin-2,3-dione 4, results into hydrazono-2-indolinones 5. Compounds 5 when subjected to Mannich reaction with different cyclic secondary amines yield 1-aminomethyl-3-benzoylhydrazono-2-indolinones 6 (Mannich bases). All these compounds (6a-i)exhibit significant antiinflammatory activity.