The Influence of Calcium Mupirocin Nasal Ointment on the Incidence ofStaphylococcus AureusInfections in Haemodialysis Patients

摘要

Mupirocin was used in haemodialysis patients in an attempt to eradicate nasal carriage ofStaphylococcus aureusand to prevent infection caused by this microorganism. The effectiveness of calcium mupirocin as a 2nasal ointment OB2 (16 patients for 104 patient-months) was compared to that of placebo (18 patients for 147 patient-months) in a double-blind study. Mupirocin or placebo were applied in both anterior nares thrice daily for 2 weeks and subsequently three times weekly for a total of 9 months. During therapy,S. aureuswas recovered from only 6of the nasal cultures in the mupirocin group compared to 58in the placebo group (P≤0.01). Only oneS. aureusinfection was documented in the mupirocin group compared to six in the placebo group (P≤0.05). TheS. aureusstrain causing the single infection in the mupirocin group was of a different phage type to that of the original nasal strain. In contrast, at least four of the six strains causing infection in the placebo group were of similar phage type to the original nasal strain. AllS. aureusisolates remained mupirocin sensitive (MIC≤1 mg/l). In conclusion, mupirocin nasal ointment was effective in eradicating nasal carriage ofS. aureusand in preventingS. aureusinfections in patients on haemodia