Synthesis and antileishmanial activity of some chromon-8-ylalkanoic acids and their methyl esters

摘要

Some new 2-(2-aryl-6-methylchromon-8-yl)alkanoic acids 7 and their methyl esters 6 have been synthesized from appropriate 8-alkanoylflavones 5 by 1,2-aryl migration of flavone ring using iodobenzene diacetate (IBD). Some of the compounds have been assayed for their in vitro antileishmanial activity on Leishmania donovam strain UR-6. Compound 7c has been found to possess promising activity.