Synthesis and studies n biological activities of some substituted 2-benzopyran-1H-one,1H-2-oxo-benzopyran-3-carboxylic acids and 2-benzofuran-1(H)-one

摘要

Prompted by the varied biological and herbicidal properties,the title compounds have been conveniently prepared by refluxing o-acyl/aroylbenzoic acids 1a-c/4a-f with substituted/unsubstituted phenacyl bromides 2a-e or diethyl bromomalonate 7 in ethyl methyl ketone in the presence of potassium carbonate.All the compounds have been screened for different biological activities.The compounds 3b-e,i,5b,d,f,and 8a,b show significant blood pressure effect on rats in vivo whereas spasmodic contraction is shown byb 3c,e,i,and 5f in rat illium in vitro.Blood anticoagulant activity,bleeding time/clotting time has also been recorded for a few compounds 3a,c,e,i.A few isocoumarins 3d,e,h,i,g have been examined against different kinds of microbes.Phthalides 5a-e show remarkable results in growth and germination of seeds pigeon pea (Tuvar Var ICP) and tritieum estium(Wheat)in the recorded period.