Synthesis and pharmacological studies of 1-p-nitrobenzoyl-3-(3-substituted-2-hydroxy-propyloximino)indole-2,3-diones

摘要

Sodium salt of 3-oximino indole-2,3-dione on reaction with epichlorohydrin in N,N'-dimethylformamide gives 3-(2,3-epoxypropyloximino)indole-2,3-dione 2.Compound 2 on reaction with diverse secondary amines yields corresponding Mannich bases 3a-e,which on benzoylation furnish 4a-e.The synthetic benzoyl derivatives of 4a-e have been screened for their pharmacological activities.