Synthesis of 2,6-dimethyl-4-substituted pyridine-3,5-dicarbonitriles from #beta#-aminoacrylonitriles

摘要

#beta#-Aminoacrylonitrile reacts with aldehydes or cinnamaldehyde in the presence of HCl to give 2,6-dimethyl-4-substituted pyridine-3,5-dicarboitrites 2a-c. 2a-b on condensation with DMF/DMA afford 8a-b. Reaction of 2b with 4-N,N-dimethylaminobenzaldehyde yields 8c. The structures of the newly synthesized compounds have been elucidated by elemental analyses and spectral data.