Thiazolidinyl-triazinoquinazolines as potent anti-inflammatory agents

摘要

Some new 5-(5'-substituted-aryl-2'-oxo-4'-thiazolidin-1'-yl)amino-4-phenyl-2-methyl-10-bromo-[1,2,4]triazino[2,3-c]quinazolines have been synthesized by [1,5]cyclocondensation of thiolactic acid with 5-arylidene hydrazino-4-phenyl-2-methyl-10-bromo[1,2,4] triazino [2,3-c] quinazolines. All the Compounds of the series have been screened for their anti-inflammatory activity. The most potent compound of the series 5-(5'-p-dimethylaminophenyl-2'-oxo-4'-thiazolindin-1'-yl)amino-4-phenyl-2-methyl-10-bromo[1,2,4] triazino[2,3-c]quinazolines has shown 48.93% activity at a dose of 50 mg/kg p.o. The structures of the products have been delineated by chemical reactions, elemental analysis and spectral studies.