Zinc mediated allylation of aldehydes and ketones using allyl bromides and commercial zinc dust. The issue of regio- and stereoselectivity

摘要

An efficient procedure for the preparation of homoallylic alcohols has been achieved by a simple reaction of an aldehyde or a ketone with allyl bromide and commercial zinc dust in tetrahydrofuran. Excellent regioselectivity has been observed in the reaction of substituted allyl bromides.