Ultrasound promoted synthesis of (±)-8-hydroxy-5-isopropyl-8-methyl-6(E)-nonen-2-one ((±)-solanone hydrate) and 3,7-dimethyl-2(E),7-octadienylpropionate

摘要

A facile synthesis of the title compounds has been accomplished using Zn-Cu couple catalyzed conjugate addition of allylic halides to alpha,beta-unsaturated ketones initiated by ultrasonic waves under aqueous conditions and Horner-Wittig reaction using ethyl alpha-dimethylphosphonoacetate and NaH as base in dry THF as the key steps in overall good yields.