Thiadiazolyl quinazolones as potential antivira and antihypertensive agents

摘要

Phthalic anhydride on treatment with beta-ethanol amine gives N-hydroxy ethyl phthalimide I which reacts with anthranilic acid in presence of ethanol containing concentrated hydrochloric acid affording 5-(N-ethylphthalimido)-anthranilic acid 2.This on treatment with benzoyl chloride in pyridine gives (6-N-ethyl phthalimido)-2-phenyl-4-oxo-3,4-dihydrobenzoxazine 3 which on reaction with 2-amino-5-aralkyl-1,3,4-thiadizoles 4 in pyridine results in the formation of 6-(N-ethydrobenzoxazine 3 -[2'-(5'-aralkyl-1',3',4'-thiadiazoly)]-2-phenyl-4-oxo-(3H)-quinazolines 5.The antiviral and antihypertensive activities of 5 have been reported.