Decrease in insulin resistance has a key role in improvement of metabolic profile during intragastric balloon treatment

摘要

To the Editor, Obesity is a chronic polygenic disease in most cases 1. Despite the different pathogenesis, all obese individuals have something in common: low growth hormone (GH) levels and increased insulin levels 2. This hormonal imbalance plays an important role in other metabolic disorders, such as glucose intolerance and dyslipidemia. Adipose tissue mass is also important factor. It is an endocrine organ that secrets several metabolic hormones and proinflammatory cytokines. The intensity of their secretion positively correlates with adipose tissue mass 3.