Investigation of Lewis Phenotypes in Polynesians: Evidence of a Weak Secretor Phenotype

摘要

Abstract.The salivary ABH and Lewis antigens of Polynesians were measured using a standardised red cell agglutination microplate assay and compared with the red cell defined Lewis phenotypes. Salivary ABH substances were detected in almost all saliva samples tested, with low levels (partial secretion) of ABH substances in the saliva from Le(a+b‐) and Le(a+b+) individuals. Salivary Lebsubstance was detected in all Le(a‐b+) and Le(a+b+) samples and in almost all Le(a+b‐) samples. It is evident from the results obtained that Polynesian red cell phenotypes cannot be used to predict the presence or absence of salivary substances.If the presence of a coding secretor gene is presumed responsible for salivary ABH antigens and salivary Lebantigen expression, then the incidence of a coding secretor gene in Polynesians is 98. These results indicate that the recessive non‐secretor gene is absent or rare in a Polynesian derived gene pool. Two variants of secretor individuals are found among Polynesians, secretors with expression of normal amounts of the product of the secretor gene, similar to Caucasians, and partial secretors with weak expression of the secretor gene p