Optical Resolution of Chlorpheniramine by Cyclodextrin Added Capillary Zone Electrophoresis and Cyclodextrin Modified Micellar Electrokinetic Chromatography

摘要

Optical resolution ofRS-chlorpheniramine by cyclodextrin (CD) added capillary zone electrophoresis (CZE) and cyclodextrin modified micellar electrokinetic chromatography (CD-MEKC) was investigated. In CD added CZE, optical resolution was achieved with #x3B2;-CD - urea solutions (pH 2.5-3.0) with and without methanol. In this system, #x3B3;-CD was not effective to achieve enantiomeric separation. In CD-MEKC, similar resolution as in the CD added CZE systems was obtained with sodium dodecyl sulfate (SDS) - #x3B2;-CD - urea solutions (pH 3.0).