Idiotypic analysis of the response of C57BL/6 mice to the (4‐hydroxy‐3‐nitrophenyl)acetyl group

摘要

AbstractStrain C57BL/6 mice produce a highly restricted primary response to the (4‐hydroxy‐3‐nitrophenyl)acetyl (NP) group. This response is composed of molecules having μ or γ1heavy chains and light chains of the λ type. A guinea pig anti‐idiotype was raised to the purified C57BL/6 primary anti‐NP immunoglobulin. After suitable absorption, this anti‐idiotype was shown to detect markers present on the primary anti‐NP immunoglobulin only of those strains which express the Ig‐lballotype. Breeding experiments demonstrated that the marker segregated with the heavy c