A novel bioabsorbable gel formed from a mixed micelle solution of poly(oxyethylene)-block-poly(L-lactide) and poly(oxyethylene)-block-poly(D- lactide) by concomitant stereocomplexation and chain extension

摘要

Furan-terminated poly(oxyethylene)-block-poly(L-lactide) (MePEG-PLLA-F) and poly(oxyethylene)-block-poly(D-lactide) (MePEG-PDLA-F) are synthesized by ring-opening polymerization of L- and D-lactides, respectively, in the presence of poly(ethylene glycol) monomethyl ether (MePEG) and the following terminal reaction with furfuryl isocyanate. Their mixed micelle solution turns to gel quickly with stereocomplexation of the enantiomeric PLLA and PDLA. When 1,8-bis(maleimido)diethylene glycol (BMG) is added to the mixed micelle solution, the gelation is promoted by the terminal coupling of the copolymers driven by the Diels-Alder reaction of the furanyl groups and BMG giving a gel having higher strength.