The purpose of this study was to investigate H(e) concentration in plasma from 80 healthy donors in relation to age (6 newborns are also included), sex, daily variation (9, 11 a.m.; 2, 6, 12 p.m.) and a period of 5 subsequent months. A significant correlation (r = 0.63, p<0.001) was observed between plasma H(e) and age and a statistical difference (p<0.05) was found between female and male. No circadian rhythm or significant variations over 5 months were found.
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