Leukocyte Iso- and Autoantibodies in Multiple Sclerosis (MS) with Special Regard to Complement-Dependent Cold-Reacting Auto-Lymphocytotoxins (CoCoCy)

摘要

Studies on leukocyte antibodies in multiple sclerosis (MS) yielded positive results in 34 of 462 MS patients who were in the chronic stage of the disease, when the sera were tested at 15 °C against homologous lymphocytes of 10 cell donors bearing different HL-A antigens. The corresponding value in healthy controls was 7. When autologous cells were used for demonstration of complement-dependant cold-reacting cytotoxins (auto-CoCoCy) the percentage of positive reactions rose up to 75. No correlation of iso-CoCoCy with the HL-A antigens could be demonstrated. CoCoCy-positive sera did not react either with homologous or autologous lymphocytes at 37 °C. CoCoCy activity in sera was destroyed by means of 2-mercaptoethanol. The biological significance of CoCoCy in MS remains unclea