Anti-oral common pathogenic bacterial active acetylenic acids from Thesium chinense Turcz

摘要

Abstract Discovery of agents for oral infectious diseases is always encouraged in natural products chemistry. A bioassay-guided isolation led to the isolation of two new acetylenic acids ( 1 , 2 ) along with seven known ones ( 3 – 9 ) from the ethanol extract of Thesium chinense Turcz, a commonly used oral anti-bacterial and anti-inflammatory herb. Their structures were elucidated on the basis of spectroscopic and chemical evidence. Exocarpic acid ( 3 ) demonstrated the most promising activity against three tested oral pathogenic bacterial strains, Porphyromonas gingivalis , Fusobacterium nucleatum , and Streptococcus mutans , with minimum inhibitory concentration values of 0.86, 3.43, and 13.70?μg/mL, respectively. Compounds 1, 2, 4, 5 and 7 also showed potential activities against periodontal bacteria ( P. gingivalis , F. nucleatum ).