Skin-lightening agents (SLA) are used to treat hyperpigmentation. Dermatologists, pharmacists, applied botanists, and allied health care researchers have discovered and undertaken various in vivo and in vitro studies on SLA. Hydroquinone, its derivatives, several plant extracts, either monotherapy or in combination are tried to achieve the skin-lightening effect and are being used in cosmetics. Each approach has its advantages and disadvantages with adverse side effects. This article analyzes the latest developments of SLA with reference to in vivo studies and clinical trials.
展开▼
