Major histocompatibility complex regulation of interleukin‐5 production in the mouse

摘要

AbstractLymph node cells of CBA (H‐2k), but not of BALB/c (H‐2d) mice immunized epicutaneously with picryl chloryde secrete interleukin (IL)‐5 when stimulated with the specific antigenin vitro. The low IL‐5 production in BALB/c mice persists when either picryl chloride or the unrelated antigen oxazolone are used, when the amount of antigenin vitrois varied and when a secondary response is studied. The difference in IL‐5 production maps to the major histocompatibility complex (MHC) in the congenic BALB/b, BALB/c and BALB/k mice. Furthermore, lymph node cells from (k × d) F1mice produce IL‐5 when stimulated by antigen presented on H‐2kbut not on H‐2dantigen‐presenting cells.Finally, the low IL‐5 productionin vitroin BALB/c mice is correlated with low picryl‐specific IgA levelsin vivo, which otherwise are ten times greater in CBA and BALB/k mice. The influence of MHC on IL‐5 production and IgA secretion in the mouse might be a possible basis for the association of MHC with