Role of Inflammatory Markers in Elderly Type 2 Diabetic Patients with Mild Cognitive Impairment

摘要

Background: Type 2 diabetes (T2DM) is a risk factor for Alzheimer’s disease and mild cognitiveimpairment. The etiology of cognitive impairment in people with T2DM is uncertain but, chronichyperglycemia, cerebral micro vascular disease, severe hypoglycemia, and increased prevalence ofmacro vascular disease are implicated.Objectives: To determine the serum levels of soluble vascular adhesion molecule (sVCAM-1) andhighly sensitive C-reactive protein (hs-CRP) in elderly type 2 diabetics with mild cognitive impairment(MCI).Methods: Our study was conducted on 90 elderly subjects (aged 60 years old or more). They were dividedinto Group ?, 30 patients with T2DM and mild cognitive impairment, group ??, 30 patients withT2DM without cognitive impairment and group III, 30 healthy subjects as a control group. They weresubjected to history taking, full clinical examination, anthropometric measurement, the Addenbrooke’sCognitive Examination III (ACE---III 2012), Fasting plasma glucose, 2 hours plasma glucose, HbA1c,lipid profile, protein/creatinine ratio, serum sVCAM-1 and hs-CRP.Results: Serum levels of sVCAM-1 in diabetic elderly patients with MCI were significantly higher(946.7 ± 162.01 ng/ml) than diabetic elderly patients without cognitive impairment (479.06 ± 65.27ng/ml) and control (263.7 ± 72.05 ng/ml) with (P=0.002). Serum levels of Hs-CRP in diabetic elderlypatients with MCI were significantly higher than as diabetic elderly patients without cognitive impairmentand control with (P=0.005).Conclusion: Elderly diabetic patients with mild cognitive impairment have higher levels of soluble adhesionmolecules and markers of low-grade systemic inflammation than other groups.