ONE-POT SYNTHESIS OF 3-FORMYLCHROMONES FROM Ws-(TRICHLOROMETHYL)CARBONATE/DMF

摘要

3-Formylchromones possess significant biological activities and have been extensively used as versatile building blocks for the synthesis of a large number of heterocyclic systems.They contain three electron-deficient sites(C-2,C-4 and the carbonyl carbon atom CHO)susceptible to nucleophilic attack.To our best knowledge,3-formylchromones have been previously synthesized in low yields from the reaction of 2-formyl-2-hydroxyacetophenones with ethyl ortho-formate and acetic anhydride.