HYPOGLYCEMIC, LIPID LOWERING AND ANTIOXIDANT ACTIVITIES IN ROOT EXTRACT OF ANTHOCEPHALUSINDICUS IN ALLOXAN INDUCED DIABETIC RATS

摘要

The present study was carried out to evaluate the hypoglycemic, lipid lowering and antioxidant activities in root extract of Anthocephalus indicus (A indicus) in alloxan indued diabetic rats. Oral administration ofethanol extract of root (500mg/ kg body weight) for 21 days resulted in significant decrease in the levels of blood glucose, triglycerides, total cholesterol, phospholipid and free fatty acids. Furthermore, the root extract (100-400mug) inhibited the generation of superoxide anions and hydroxyl radicals, in both enzymic and non-enzymic systems, in vitro. The result of the present study demonstrated hypoglycemic, lipid lowering and antioxidant activities in root extract of A indicus, which could help in prevention of diabetic dyslipidemia and related diseases.