In Viva Anti-Aging Efficacyof a Cyclic Peptide Composition

摘要

Aging affects the composition and morphological structure of the different compartments of the skin. Inte-grins, as an important family of transmembrane receptors, play a key role in cell-matrix interactions and are involved in cell signaling. Binding of specific ligands within the extracellular matrix to these receptors is a crucial step to maintain a vital tissue structure. For this reason a selective cyclic peptide containing an arginine-glycine-aspartic acid (RGD) sequencewas designed for cosmetic applications.The objective of the present work was to evaluate the binding efficiency of different RGD peptides to specific in-tegrins. The cyclic RGD peptide was tested in a placebo-controlled study with human volunteers with respect to its anti-aging efficacy in vivo. The results of the ligand inhibition assay with immobilized integrins clearly demonstrated that only the cyclic conformation of the RGD motif selec-tively binds to the integrin receptors. In terms of anti-aging properties, this in vivo trial confirmed the results of previous in vitro investigations where a positive effect on wrinkle reduction was observed. Our present work again supports the hypothesis that this specific RGD peptide composition successfully mimics the biological function of extracellular matrix proteins by activating signaling pathways and targets involved in the prevention of aging.