Identification of Novel mRNA Transcripts of thenm23-M1Gene that Are Modulated during Mouse Embryo Development and Are Differently Expressed in Adult Murine Tissues

摘要

Thenm23-M1, a putative metastasis-suppressor gene, and its homologs are involved in development and differentiation. We have shown previously thatin vitroneuronal cell proliferation and differentiation can be modulated bynm23-M1expression levels. In the present study, by the yeast two-hybrid system, we have shown that, at the onset of mouse tissue differentiation, the Nm23-M1 protein forms either homodimers, or heterodimers with Nm23-M2. Furthermore, we have isolated two cDNA variants of thenm23-M1gene in the 3′-untranslated region (UTR). The two variants related to novel mRNA transcripts that are modulated in mouse embryo and are differently expressed in adult murine tissue