SummaryAtopy is associated with diminished cell‐mediated immunity and increased amounts of IgE, both of which may be caused by imbalances of T lymphocyte subsets.We compared the composition of highly purified peripheral‐blood T cells of fifteen atopic asthmatics with ten non‐atopic control subjects. Each subject was examined on five separate occasions. Indirect immunofluorescence using monoclonal antibodies was used to define T cell subsets. We examined the proportion of T cells with T3 (most T cells), T4 (helper/inducer), T8 (suppressor/cytotoxic), M1 (natural killer), and Ia (activated T cells) surface antigens. Blood was obtained at the same time of day to eliminate the effects of circadian rhythm. Subjects were taking no medications.We found no difference between the groups of the percentage of T cells with T4, T8, M1, and Ia antigens, nor the ratio of T4+ (helper) to T8+ (suppressor) cells. T3 percent was slightly (94.3vs92.5) higher in the atopic group. We conclude that atopic asthma is not associated with imbalances of peripheral‐blood T cell
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机译:摘要特应性与细胞介导的免疫力减弱和 IgE 量增加有关,这两者都可能是由 T 淋巴细胞亚群失衡引起的。我们比较了 15 名特应性哮喘患者和 10 名非特应性对照受试者高度纯化的外周血 T 细胞的组成。每个受试者在五个不同的场合进行了检查。使用单克隆抗体的间接免疫荧光来定义 T 细胞亚群。我们检查了具有 T3(大多数 T 细胞)、T4(辅助/诱导剂)、T8(抑制因子/细胞毒性)、M1(自然杀伤)和 Ia(活化 T 细胞)表面抗原的 T 细胞比例。在一天中的同一时间获得血液以消除昼夜节律的影响。受试者没有服用任何药物。我们发现具有 T4、T8、M1 和 Ia 抗原的 T 细胞百分比在两组之间没有差异,T4+(辅助细胞)与 T8+(抑制细胞)的比例也没有差异。特应性组的T3%略高(94.3%vs92.5%)。我们得出结论,特应性哮喘与外周血T细胞失衡无关
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