BTLA(+) Dendritic Cells: The Regulatory T Cell Force Awakens

摘要

The role of dendritic cells (DCs) in the induction of antigen-specific tolerance mediated by extrathymic regulatory T (Treg) cells remains incompletely defined. In this issue of Immunity, Jones et al. (2016) show that BTLA(+)DEC205(+)CD8(+)CD11c(+) DCs efficiently induce peripheral Treg cells via the engagement of HVEM, a receptor for BTLA.