Mechanistic Insights for Drug Repurposing and the Design of Hybrid Drugs for Alzheimer?s Disease

摘要

The heterogeneity and complex nature of Alzheimer's disease (AD) isattributed to several genetic risk factors and molecular culprits. The slow pace and increasingfailure rate of conventional drug discovery has led to the exploration of complementarystrategies based on repurposing approved drugs to treat AD. Drug repurposing (DR) is a cost-effective, low-risk, and efficient approach for identifying novel therapeutic candidates for ADtreatment. Similarly, hybrid drug design through the integration of distinct pharmacophoresfrom known or failed drugs and natural products is an interesting strategy to target themultifactorial nature of AD. In this Perspective, we discuss the potential of DR and highlightpromising drug candidates that can be advanced for clinical trials, backed by a detaileddiscussion on their plausible mechanisms of action. Our article fosters research on the hiddenpotential of DR and hybrid drug design with the goal of unravelling new drugs and targets totackle AD