3D bioprintable methacrylated carrageenan/sodium alginate dual network hydrogel for vascular tissue engineering scaffolding

摘要

3D printing technology has significant advantages in the processing field of vascular tissue engineering. We have developed KCMA/SA hydrogels based on methacrylated carrageenan (KCMA) and sodium alginate (SA), which have low viscosity and shear thinning properties and can be used for 3D printing. The physicochemical double cross-linked network structure leads to good mechanical properties. The composite hydrogels maintain the liquid crystallinity of KC, which causes the HUVECs to align. The KCMA/SA gel filaments printed by the 3D extrusion printing system formed a connected microstructure. These characteristics all indicate the potential of KCMA/SAs in the field of tubular tissue regeneration.